MOTS-C 40mg

The mitochondrial peptide. Encoded in mitochondrial DNA. An exercise mimetic that works at the energy source.

$ 149.00

Personalized guidance 1 on 1

Full refund if our licensed clinician determines the treatment isn’t a fit for you

MOA

Overview

MOTS-C is a mitochondrial-derived peptide encoded directly in mitochondrial DNA — making it unique among peptides in that it originates outside the nuclear genome entirely. It functions as a signalling molecule communicating metabolic stress from the mitochondria to the rest of the cell, triggering adaptive responses that improve energy efficiency, insulin sensitivity, and stress resilience. It is frequently described in research literature as an “exercise mimetic” — activating many of the same metabolic pathways as physical exercise, without providing the mechanical stimulus for muscle growth.

What it does

MOTS-C production increases in response to low glucose, exercise, oxidative stress, and mitochondrial dysfunction. It activates AMPK — the master metabolic regulator — improving mitochondrial health, enhancing fat and glucose utilisation, increasing insulin sensitivity, and promoting metabolic flexibility. In aging research, it counteracts age-related mitochondrial decline by improving mitochondrial signalling and energy production. It has been described in longevity research as one of the most promising mitochondrially-encoded regulators of biological aging.

Research areas

Mitochondrial function and biogenesis · Insulin resistance and metabolic syndrome · Obesity and energy metabolism research · Anti-aging and longevity · Endurance performance research · Caloric deficit and body composition protocols

Key facts

Form	Lyophilised powder — requires reconstitution with bacteriostatic water
Storage	Lyophilised: -20°C. Reconstituted: 2–8°C, use within 21 days
Purity	≥99% — third-party COA verified, batch-specific documentation included
Note	WADA prohibited — not suitable for competitive athletes subject to anti-doping rules

For research use only. Not for human consumption. This product is not approved for human use by the FDA or any regulatory body.

More Information

All products offered on this website are intended solely for laboratory research and development purposes. They are not approved for human or veterinary use.

Statements on this site have not been evaluated by the U.S. Food and Drug Administration (FDA). Products are not intended to diagnose, treat, cure, mitigate, or prevent any disease.

Products are manufactured in U.S.-based facilities operating under applicable cGMP standards. This website does not operate as a compounding pharmacy under Section 503A of the Federal Food, Drug, and Cosmetic Act.

A valid health screening is required prior to order fulfillment. After checkout, you will receive instructions to complete the required intake process. Orders will be processed once the screening has been completed and approved. Each completed screening remains valid for 12 months.